Summary of study ST000095

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Study IDST000095
Study TitleDysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome
Study TypeChemical dosage and feeding study
Study SummaryTargeted metabolomic analysis of bile acids was performed on 15 mouse liver samples collected from mice euthanized at 9 months following consumption of a high fat diet w/o perinatal DDT exposure. Funded by the National Institute of Health (R00 ES019919, R03 DK082724, U24 DK092993, U24 DK097154, T32 ES007059, and P60 DK020541), the American Diabetes Association, and USDA-ARS intramural Project 5306-51530-019-00D. Samples were analyzed by UPLC-MS/MS using a Waters Acquity UPLC and detected on an API 4000 QTrap (AB Sciex, Framingham, MA, USA) by multiple reaction monitoring (MRM) after negative mode electrospray ionization.
InstituteUniversity of California, Davis
DepartmentU.S.D.A. Western Human Nutrition Research Center
LaboratoryNewman
Last NameJohn
First NameNewman
Address430 W. Health Sciences Dr., Davis, CA 95616
Emailjohn.newman@ars.usda.gov
Phone+1-530-752-1009
Submit Date2014-07-10
Num Groups2
Total Subjects15
Raw Data AvailableYes
Raw Data File Type(s)mzML
Uploaded File Size23 M
Release Date2015-02-03
Release Version1

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Project:

Project ID:PR000087
Project DOI:doi: 10.21228/M8F30Z
Project Title:Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome
Project Type:Animal chemical exposure and feeding study
Project Summary:This study evaluated the effect of perinatal DDT exposure on metabolic syndrome in mice exposed to doses that mimicked human exposure. The samples tested were from 2 groups: 1) a group with perinatal exposure to DDT consuming a high fat diet (DDHF), 2) a control group consuming a high fat diet (CHF). Results indicated the DDHF group had comparatively elevated plasma concentrations of glucose, insulin, cholesterol, and triglycerides, CYP7A1 gene expression, homeostasis model assessment- insulin resistance (HOMA-IR), and fat mass (%), as well as reduced thermogenesis. These data suggest perinatal DDT exposure may cause the co-occurrence of conditions associated with metabolic syndrome, including glucose intolerance, hyperinsulinemia, and dyslipidemia, impaired thermogenesis, and obesity.
Institute:University of California, Davis
Department:Environmental Toxicology
Laboratory:La Merrill
Last Name:La Merrill
First Name:Michele
Address:1 Shields Ave, Davis CA
Email:mlamerrill@ucdavis.edu
Phone:+1-530-754-7254
Funding Source:National Institute of Health (R00 ES019919, R03 DK082724, U24 DK092993, U24 DK097154, T32 ES007059, and P60 DK020541), the American Diabetes Association, and USDA-ARS intramural Project 5306-51530-019-00D
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