Summary of study ST001301

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000882. The data can be accessed directly via it's Project DOI: 10.21228/M8PD88 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001301
Study TitleLuminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody
Study SummaryLuminal (fecal) metabolome of anti-IL-22 antibody-treated HMA mice and control antibody-treated HMA mice were compared.
Institute
University of Michigan
DepartmentInternal Medicine
Last NameKamada
First NameNobuhiko
Address1150 W Medical center Dr, Ann Arbor, MI 48109, USA
Emailnkamada@umich.edu
Phone+1-734-763-2142
Submit Date2019-12-22
Raw Data AvailableYes
Raw Data File Type(s).d
Analysis Type DetailLC-MS
Release Date2020-01-08
Release Version1
Nobuhiko Kamada Nobuhiko Kamada
https://dx.doi.org/10.21228/M8PD88
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000882
Project DOI:doi: 10.21228/M8PD88
Project Title:Luminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody
Project Summary:We found that healthy (HC)-HMA mice, GF mice were colonized with gut microbiota derived from human HC, were protected from Clostridioides difficile (C. difficile) infection. However, the colonization resistance of HC-HMA mice was abolished by treatment of anti-IL-22 antibody, unlike control antibody-treated HC-HMA mice. Additionally, the gut microbial composition of anti-IL22 antibody-treated HC-HMA mice, C. difficile-susceptible mice, were differ from that of control antibody, thereby it appears that luminal metabolome is changed between 2 groups. To examine the change in the luminal metabolites, fecal samples were collected from anti-IL-22 /control -antibody treated HC-HMA mice, and metabolite profiles of them were analyzed.
Institute:University of Michigan
Department:Internal Medicine
Last Name:Kamada
First Name:Nobuhiko
Address:1150 W Medical center Dr, Ann Arbor, MI 48109, USA
Email:nkamada@umich.edu
Phone:+1-734-763-2142
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