MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000090

UniProt Annotations

Entry Information
Gene Nameadenylosuccinate synthase
Protein EntryPURA2_HUMAN
UniProt IDP30520
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityGTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. {ECO:0000255|HAMAP-Rule:MF_03127}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_03127}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP- Rule:MF_03127};
FunctionPlays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
InteractionQ8NB12:SMYD1; NbExp=2; IntAct=EBI-1042898, EBI-8463848;
PathwayPurine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03127}.
SimilarityBelongs to the adenylosuccinate synthetase family. {ECO:0000255|HAMAP-Rule:MF_03127}.
Subcellular LocationCytoplasm. Note=Partially associated with particulate fractions.
SubunitHomodimer. {ECO:0000255|HAMAP-Rule:MF_03127}.
  logo