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MGP000109

Record overview

MGPD IDMGP000109
Gene ID208
SpeciesHomo sapiens (Human)
Gene Namev-akt murine thymoma viral oncogene homolog 2
Gene Symbol AKT2
SynonymsPKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA;
Alternate namesRAC-beta serine/threonine-protein kinase; PKB beta; RAC-PK-beta; protein kinase Akt-2; protein kinase B beta; rac protein kinase beta; murine thymoma viral (v-akt) homolog-2;
Chromosome19
Map Location19q13.1-q13.2
EC Number2.7.11.1
SummaryThis gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AKT2

Proteins

RAC-beta serine/threonine-protein kinase isoform 1
Refseq ID:NP_001617
Protein GI:4502023
UniProt ID:P31751
mRNA ID:NM_001626
Length:481
RefSeq Status:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWM
RAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTE
SRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDA
KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
 
RAC-beta serine/threonine-protein kinase isoform 2
Refseq ID:NP_001229956
Protein GI:339895853
UniProt ID:B4DG79
mRNA ID:NM_001243027
Length:419
RefSeq Status:
MKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGT
FGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSA
LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI
LMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLL
ELDQRTHFPQFSYSASIRE
 
RAC-beta serine/threonine-protein kinase isoform 2
Refseq ID:NP_001229957
Protein GI:339895855
UniProt ID:B4DG79
mRNA ID:NM_001243028
Length:419
RefSeq Status:
Protein sequence is identical to GI:339895853 (mRNA isoform)
 
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