MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000109

Ontology/Pathway Information

Entrez Gene ID208
Gene Namev-akt murine thymoma viral oncogene homolog 2
Gene Symbol AKT2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005938 ISS:UniProtKBCcell cortex
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0032587 ISS:UniProtKBCruffle membrane
GO:0005524 IDA:UniProtKBFATP binding
GO:0016301 TAS:ReactomeFkinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0032859 IEA:EnsemblPactivation of Ral GTPase activity
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0008643 IEA:UniProtKB-KWPcarbohydrate transport
GO:0006464 TAS:ProtIncPcellular protein modification process
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0045444 TAS:UniProtKBPfat cell differentiation
GO:0006006 IEA:UniProtKB-KWPglucose metabolic process
GO:0005978 IEA:UniProtKB-KWPglycogen biosynthetic process
GO:0008286 TAS:UniProtKBPinsulin receptor signaling pathway
GO:0065002 ISS:UniProtKBPintracellular protein transmembrane transport
GO:0060644 TAS:UniProtKBPmammary gland epithelial cell differentiation
GO:0061024 TAS:ReactomePmembrane organization
GO:0010748 IMP:BHF-UCLPnegative regulation of plasma membrane long-chain fatty acid transport
GO:0032287 IEA:EnsemblPperipheral nervous system myelin maintenance
GO:2000147 IMP:BHF-UCLPpositive regulation of cell motility
GO:0032000 IMP:BHF-UCLPpositive regulation of fatty acid beta-oxidation
GO:0046326 IMP:BHF-UCLPpositive regulation of glucose import
GO:2001275 IEA:EnsemblPpositive regulation of glucose import in response to insulin stimulus
GO:0010907 IMP:BHF-UCLPpositive regulation of glucose metabolic process
GO:0045725 IMP:BHF-UCLPpositive regulation of glycogen biosynthetic process
GO:0001934 ISS:UniProtKBPpositive regulation of protein phosphorylation
GO:0090314 ISS:UniProtKBPpositive regulation of protein targeting to membrane
GO:0031340 ISS:UniProtKBPpositive regulation of vesicle fusion
GO:0072659 IEA:EnsemblPprotein localization to plasma membrane
GO:0071156 TAS:UniProtKBPregulation of cell cycle arrest
GO:0030334 TAS:UniProtKBPregulation of cell migration
GO:0006417 IEA:UniProtKB-KWPregulation of translation
GO:0007165 TAS:UniProtKBPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_549Activation of BAD and translocation to mitochondria
REACT_697Activation of BH3-only proteins
REACT_790Activation of PKB
REACT_75774Adaptive Immune System
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_12564AKT phosphorylates targets in the cytosol
REACT_12442AKT phosphorylates targets in the nucleus
REACT_578Apoptosis
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_264178deactivation of the beta-catenin transactivating complex
REACT_111045Developmental Biology
REACT_116125Disease
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6743Inhibition of TSC complex formation by PKB
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_964Intrinsic Pathway for Apoptosis
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_11123Membrane Trafficking
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_6838mTOR signalling
REACT_12447Negative regulation of the PI3K/AKT network
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_1451PDE3B signalling
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_456PKB-mediated events
REACT_798Platelet activation, signaling and aggregation
REACT_268456Programmed Cell Death
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264596TCF dependent signaling in response to WNT
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
  logo