MGP Database

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MGP000153

UniProt Annotations

Entry Information
Gene Namesolute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
Protein EntryADT2_HUMAN
UniProt IDP05141
SpeciesHuman
Comments
Comment typeDescription
FunctionCatalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000269|PubMed:20797633}.
InteractionQ5S007:LRRK2; NbExp=2; IntAct=EBI-355133, EBI-5323863; Q9Y6E7:SIRT4; NbExp=2; IntAct=EBI-355133, EBI-2606540; Q8N357:SLC35F6; NbExp=2; IntAct=EBI-355133, EBI-713484;
MiscellaneousThe transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity). {ECO:0000250}.
SimilarityBelongs to the mitochondrial carrier (TC 2.A.29) family. {ECO:0000305}.
SimilarityContains 3 Solcar repeats. {ECO:0000255|PROSITE- ProRule:PRU00282}.
Subcellular LocationMitochondrion inner membrane; Multi-pass membrane protein.
SubunitHomodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with HIV-1 Vpr. {ECO:0000269|PubMed:16120388, ECO:0000269|PubMed:20797633}.
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