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MGP000229

Record overview

MGPD IDMGP000229
Gene ID466
SpeciesHomo sapiens (Human)
Gene Nameactivating transcription factor 1
Gene Symbol ATF1
SynonymsTREB36; EWS-ATF1; FUS/ATF-1;
Alternate namescyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1;
Chromosome12
Map Location12q13
SummaryThis gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]
OrthologsView orthologs and multiple alignments for ATF1

Proteins

cyclic AMP-dependent transcription factor ATF-1
Refseq ID:NP_005162
Protein GI:4885073
UniProt ID:P18846
mRNA ID:NM_005171
Length:271
RefSeq Status:
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTP
IYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPV
TLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
 
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