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MGP000229

UniProt Annotations

Entry Information
Gene Nameactivating transcription factor 1
Protein EntryATF1_HUMAN
UniProt IDP18846
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P18846-1; Sequence=Displayed; Name=2; IsoId=P18846-2; Sequence=VSP_055559; Note=No experimental confirmation available.;
DiseaseAngiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
FunctionThis protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.
InteractionP03259-2:- (xeno); NbExp=2; IntAct=EBI-852794, EBI-7225021;
PtmPhosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. {ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:8621702}.
Sequence CautionSequence=CAC15058.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the bZIP family. ATF subfamily. {ECO:0000305}.
SimilarityContains 1 bZIP (basic-leucine zipper) domain. {ECO:0000255|PROSITE-ProRule:PRU00978}.
SimilarityContains 1 KID (kinase-inducible) domain. {ECO:0000255|PROSITE-ProRule:PRU00312}.
Subcellular LocationNucleus.
SubunitBinds DNA as a dimer. Interacts with HIPK2 and CDK3. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ATF1ID81.html";
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