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MGP000456

UniProt Annotations

Entry Information
Gene NameCD14 molecule
Protein EntryCD14_HUMAN
UniProt IDP08571
SpeciesHuman
Comments
Comment typeDescription
FunctionIn concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. {ECO:0000269|PubMed:23264655}.
InteractionQ12841:FSTL1; NbExp=3; IntAct=EBI-3905196, EBI-2349801;
PtmN- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169}.
SimilarityContains 11 LRR (leucine-rich) repeats. {ECO:0000305}.
Subcellular LocationCell membrane; Lipid-anchor, GPI-anchor.
SubunitBelongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.
Tissue SpecificityExpressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Web ResourceName=Wikipedia; Note=CD14 entry; URL="http://en.wikipedia.org/wiki/CD14";
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