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MGP000548

UniProt Annotations

Entry Information
Gene Namecholinergic receptor, muscarinic 1
Protein EntryACM1_HUMAN
UniProt IDP11229
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11229-1; Sequence=Displayed; Name=2; IsoId=P11229-2; Sequence=VSP_056651; Note=No experimental confirmation available.;
FunctionThe muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
SimilarityBelongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
SubunitInteracts with GPRASP2. {ECO:0000269|PubMed:15086532}.
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