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MGP000597

UniProt Annotations

Entry Information
Gene Namechemokine (C-C motif) receptor 1
Protein EntryCCR1_HUMAN
UniProt IDP32246
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
InductionUp-regulated by CREB3. {ECO:0000269|PubMed:18587271}.
InteractionO43889-2:CREB3; NbExp=7; IntAct=EBI-608322, EBI-625022; Q04941:PLP2; NbExp=3; IntAct=EBI-608322, EBI-608347;
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:18587271}; Multi-pass membrane protein {ECO:0000269|PubMed:18587271}.
SubunitInteracts with CREB3. {ECO:0000269|PubMed:15001559}.
Tissue SpecificityWidely expressed in different hematopoietic cells.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CCR1ID44379ch3p21.html";
Web ResourceName=Wikipedia; Note=CC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CC_chemokine_receptors";
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