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MGP000675

UniProt Annotations

Entry Information
Gene Namecomplement component (3b/4b) receptor 1 (Knops blood group)
Protein EntryCR1_HUMAN
UniProt IDP17927
SpeciesHuman
Comments
Comment typeDescription
FunctionMediates cellular binding of particles and immune complexes that have activated complement.
PolymorphismCR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.
PolymorphismGenetic variations in CR1 resulting in CR1 deficiency are involved in protection against severe malaria [MIM:611162]. Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as rosettes. CR1-deficient red blood cells show greatly reduced rosetting and CR1 deficiency occurs in healthy individuals from malaria-endemic regions.
PolymorphismOther polymorphic forms of CR1 contain 23, 37 or 44 Sushi (CCP/SCR) domains instead of the 30 Sushi (CCP/SCR) domains. The most frequent alleles are the F allotype (shown here) and the S allotype (37 repeat Sushi domains). The gene frequencies of the F allotype and S allotype are 0.87 and 0.11 in Caucasians, 0.82 and 0.11 in African Americans, 0.89 and 0.11 in Mexicans.
SimilarityBelongs to the receptors of complement activation (RCA) family. {ECO:0000305}.
SimilarityContains 30 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitMonomer.
Tissue SpecificityPresent on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.
Web ResourceName=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=knops";
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