MGP Database

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MGP000686

UniProt Annotations

Entry Information
Gene Namev-crk avian sarcoma virus CT10 oncogene homolog-like
Protein EntryCRKL_HUMAN
UniProt IDP46109
SpeciesHuman
Comments
Comment typeDescription
FunctionMay mediate the transduction of intracellular signals.
InteractionP00519:ABL1; NbExp=2; IntAct=EBI-910, EBI-375543; P22681:CBL; NbExp=2; IntAct=EBI-910, EBI-518228; Q96PD2:DCBLD2; NbExp=3; IntAct=EBI-910, EBI-8536103; P00533:EGFR; NbExp=3; IntAct=EBI-910, EBI-297353; P04626:ERBB2; NbExp=2; IntAct=EBI-910, EBI-641062; P21860:ERBB3; NbExp=3; IntAct=EBI-910, EBI-720706; P17948:FLT1; NbExp=9; IntAct=EBI-910, EBI-1026718; Q13480:GAB1; NbExp=4; IntAct=EBI-910, EBI-517684; Q08460:Kcnma1 (xeno); NbExp=5; IntAct=EBI-910, EBI-1633915; Q9EQG6:Kidins220 (xeno); NbExp=2; IntAct=EBI-910, EBI-976654; Q92918:MAP4K1; NbExp=5; IntAct=EBI-910, EBI-881; P16234:PDGFRA; NbExp=3; IntAct=EBI-910, EBI-2861522; P27986:PIK3R1; NbExp=2; IntAct=EBI-910, EBI-79464; Q05397:PTK2; NbExp=2; IntAct=EBI-910, EBI-702142; Q13905:RAPGEF1; NbExp=2; IntAct=EBI-910, EBI-976876; Q07889:SOS1; NbExp=2; IntAct=EBI-910, EBI-297487;
SimilarityBelongs to the CRK family. {ECO:0000305}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SimilarityContains 2 SH3 domains. {ECO:0000255|PROSITE- ProRule:PRU00192}.
SubunitInteracts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4. {ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:11443118, ECO:0000269|PubMed:12393632, ECO:0000269|PubMed:9614078}.
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