MGP Database

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MGP000700

Ontology/Pathway Information

Entrez Gene ID1452
Gene Namecasein kinase 1, alpha 1
Gene Symbol CSNK1A1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:UniProtKBCcentrosome
GO:0000777 IEA:UniProtKB-SubCellCcondensed chromosome kinetochore
GO:0005829 TAS:ReactomeCcytosol
GO:0016020 IDA:UniProtKBCmembrane
GO:0016607 IDA:UniProtKBCnuclear speck
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004672 ISS:UniProtKBFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0007166 TAS:ProtIncPcell surface receptor signaling pathway
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0007165 NAS:ProtIncPsignal transduction
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_267753Activation of SMO
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_11065Beta-catenin phosphorylation cascade
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_267700Degradation of GLI2 by the proteasome
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_268323Hedgehog 'off' state
REACT_268718Hedgehog 'on' state
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_264508Signaling by Hedgehog
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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