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MGP000700

UniProt Annotations

Entry Information

Gene Name	casein kinase 1, alpha 1
Protein Entry	KC1A_HUMAN
UniProt ID	P48729
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P48729-1; Sequence=Displayed; Name=2; IsoId=P48729-2; Sequence=VSP_035455; Note=Contains a phosphoserine at position 156.; Name=3; IsoId=P48729-3; Sequence=VSP_055131;
Catalytic Activity	ATP + a protein = ADP + a phosphoprotein.
Function	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. {ECO:0000269\|PubMed:11955436, ECO:0000269\|PubMed:1409656, ECO:0000269\|PubMed:18305108}.
Interaction	Q00987:MDM2; NbExp=3; IntAct=EBI-2040168, EBI-389668; O15151:MDM4; NbExp=2; IntAct=EBI-1383726, EBI-398437; Q13546:RIPK1; NbExp=5; IntAct=EBI-1383726, EBI-358507;
Similarity	Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. {ECO:0000305}.
Similarity	Contains 1 protein kinase domain. {ECO:0000255\|PROSITE-ProRule:PRU00159}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.
Subunit	Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. {ECO:0000269\|PubMed:18305108}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/CSNK1A1ID40168ch5q32.html";