MGP Database

MGP000732

Record overview

MGPD IDMGP000732
Gene ID1514
SpeciesHomo sapiens (Human)
Gene Namecathepsin L
Gene Symbol CTSL
SynonymsMEP; CATL; CTSL1;
Alternate namescathepsin L1; major excreted protein;
Chromosome9
Map Location9q21.33
EC Number3.4.22.15
SummaryThe protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
OrthologsView orthologs and multiple alignments for CTSL

Proteins

cathepsin L1 isoform 1 preproprotein
Refseq ID:NP_666023
Protein GI:22202619
UniProt ID:P07711
mRNA ID:NM_145918
Length:333
RefSeq Status:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKP
RKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEE
SYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1706
peptide sequence: 
MNPTLILAAFCLGIASA

mat_peptide: 114..288
product: cathepsin L1 heavy chain
calculated_mol_wt: 19080
peptide sequence: 
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
cathepsin L1 isoform 1 preproprotein
Refseq ID:NP_001244901
Protein GI:384081594
UniProt ID:P07711
mRNA ID:NM_001257972
Length:333
RefSeq Status:
Protein sequence is identical to GI:22202619 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1706
peptide sequence: 
MNPTLILAAFCLGIASA

mat_peptide: 114..288
product: cathepsin L1 heavy chain
calculated_mol_wt: 19080
peptide sequence: 
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
cathepsin L1 isoform 1 preproprotein
Refseq ID:NP_001903
Protein GI:4503155
UniProt ID:P07711
mRNA ID:NM_001912
Length:333
RefSeq Status:
Protein sequence is identical to GI:22202619 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1706
peptide sequence: 
MNPTLILAAFCLGIASA

mat_peptide: 114..288
product: cathepsin L1 heavy chain
calculated_mol_wt: 19080
peptide sequence: 
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
cathepsin L1 isoform 1 preproprotein
Refseq ID:NP_001244900
Protein GI:384081592
UniProt ID:P07711
mRNA ID:NM_001257971
Length:333
RefSeq Status:
Protein sequence is identical to GI:22202619 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1706
peptide sequence: 
MNPTLILAAFCLGIASA

mat_peptide: 114..288
product: cathepsin L1 heavy chain
calculated_mol_wt: 19080
peptide sequence: 
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
cathepsin L1 isoform 2
Refseq ID:NP_001244902
Protein GI:384081596
UniProt ID:Q9HBQ7
mRNA ID:NM_001257973
Length:151
RefSeq Status:
MDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVG
YGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1706
peptide sequence: 
MNPTLILAAFCLGIASA

mat_peptide: 114..288
product: cathepsin L1 heavy chain
calculated_mol_wt: 19080
peptide sequence: 
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1706 peptide sequence: MNPTLILAAFCLGIASA mat_peptide: 114..288 product: cathepsin L1 heavy chain calculated_mol_wt: 19080 peptide sequence: APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFEST mat_peptide: 292..333 product: cathepsin L1 light chain calculated_mol_wt: 4776 peptide sequence: NNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
 
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