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MGP000732

UniProt Annotations

Entry Information

Gene Name	cathepsin L
Protein Entry
UniProt ID	Q9HBQ7
Species	Human

Comments

Comment type	Description
Catalytic Activity	Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg- NHMec, and no peptidyl-dipeptidase activity.
Function	Important for the overall degradation of proteins in lysosomes.
Interaction	G5EFH4:srp-6 (xeno); NbExp=2; IntAct=EBI-1220160, EBI-1549936;
Similarity	Belongs to the peptidase C1 family. {ECO:0000255\|PROSITE-ProRule:PRU10088, ECO:0000255\|PROSITE- ProRule:PRU10089, ECO:0000255\|PROSITE-ProRule:PRU10090}.
Subcellular Location	Lysosome.
Subunit	Dimer of a heavy and a light chain linked by disulfide bonds.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSL1ID40208ch9q21.html";