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MGP000814

UniProt Annotations

Entry Information
Gene Namedefensin, alpha 3, neutrophil-specific
Protein EntryDEF3_HUMAN
UniProt IDP59666
SpeciesHuman
Comments
Comment typeDescription
FunctionDefensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15894545, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:2006422}.
SimilarityBelongs to the alpha-defensin family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitDimer. {ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:2006422}.
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