MGP Database

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MGP000937

Ontology/Pathway Information

Entrez Gene ID1973
Gene Nameeukaryotic translation initiation factor 4A1
Gene Symbol EIF4A1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0016281 TAS:UniProtKBCeukaryotic translation initiation factor 4F complex
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008026 IEA:InterProFATP-dependent helicase activity
GO:0003725 IDA:MGIFdouble-stranded RNA binding
GO:0004386 TAS:UniProtKBFhelicase activity
GO:0003729 TAS:UniProtKBFmRNA binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0000339 TAS:UniProtKBFRNA cap binding
GO:0008135 TAS:UniProtKBFtranslation factor activity, nucleic acid binding
GO:0003743 IEA:UniProtKB-KWFtranslation initiation factor activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0010467 TAS:ReactomePgene expression
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0000288 TAS:ReactomePnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 TAS:ReactomePnuclear-transcribed mRNA poly(A) tail shortening
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0006412 TAS:ReactomePtranslation
GO:0006413 TAS:ReactomePtranslational initiation
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1258Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_2099Cap-dependent Translation Initiation
REACT_75790Cytokine Signaling in Immune system
REACT_20639Deadenylation-dependent mRNA decay
REACT_20514Deadenylation of mRNA
REACT_2159Eukaryotic Translation Initiation
REACT_71Gene Expression
REACT_2085GTP hydrolysis and joining of the 60S ribosomal subunit
REACT_6900Immune System
REACT_25229Interferon Signaling
REACT_115831ISG15 antiviral mechanism
REACT_79L13a-mediated translational silencing of Ceruloplasmin expression
REACT_17015Metabolism of proteins
REACT_931Ribosomal scanning and start codon recognition
REACT_1014Translation
REACT_1979Translation initiation complex formation
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