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MGP000937

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation initiation factor 4A1
Protein EntryIF4A1_HUMAN
UniProt IDP60842
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P60842-1; Sequence=Displayed; Name=2; IsoId=P60842-2; Sequence=VSP_046032; Note=No experimental confirmation available.;
Catalytic ActivityATP + H(2)O = ADP + phosphate.
Enzyme RegulationHelicase activity and function in translation are inhibited by interaction with PDCD4. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
FunctionATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. {ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291}.
InteractionQ04637:EIF4G1; NbExp=7; IntAct=EBI-73449, EBI-73711; P78344:EIF4G2; NbExp=3; IntAct=EBI-73449, EBI-296519; Q15056:EIF4H; NbExp=2; IntAct=EBI-73449, EBI-748492;
SimilarityBelongs to the DEAD box helicase family. eIF4A subfamily. {ECO:0000305}.
SimilarityContains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00541}.
SimilarityContains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00542}.
SubuniteIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69. {ECO:0000269|PubMed:11073994, ECO:0000269|PubMed:11408474, ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:17284590, ECO:0000269|PubMed:19153607, ECO:0000269|PubMed:19204291, ECO:0000269|PubMed:20133758, ECO:0000269|PubMed:9548260}.
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