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MGP Database

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MGP001045

UniProt Annotations

Entry Information

Gene Name	Fc fragment of IgE, low affinity II, receptor for (CD23)
Protein Entry	FCER2_HUMAN
UniProt ID	P06734
Species	Human

Comments

Comment type	Description
Function	Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Miscellaneous	There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.
Ptm	N- and O-glycosylated.
Ptm	The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
Sequence Caution	Sequence=AAA52433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Contains 1 C-type lectin domain. {ECO:0000255\|PROSITE- ProRule:PRU00040}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note=Also exists as a soluble excreted form, sCD23.
Subunit	Homotrimer. {ECO:0000269\|PubMed:16172256, ECO:0000269\|PubMed:16765898}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FCER2ID44222ch19p13.html";
Web Resource	Name=Functional Glycomics Gateway - Glycan Binding; Note=CD23; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_221";