MGP Database

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MGP001065

Ontology/Pathway Information

Entrez Gene ID2246
Gene Namefibroblast growth factor 1 (acidic)
Gene Symbol FGF1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005938 IEA:UniProtKB-SubCellCcell cortex
GO:0005829 IDA:UniProtKBCcytosol
GO:0005576 IDA:UniProtKBCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005654 IDA:HPACnucleoplasm
GO:0005104 IPI:MGIFfibroblast growth factor receptor binding
GO:0008083 IDA:UniProtKBFgrowth factor activity
GO:0008201 IDA:UniProtKBFheparin binding
GO:0044548 IPI:UniProtKBFS100 protein binding
GO:0009653 TAS:ProtIncPanatomical structure morphogenesis
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0060681 IDA:UniProtKBPbranch elongation involved in ureteric bud branching
GO:0030154 IEA:UniProtKB-KWPcell differentiation
GO:0034605 IDA:UniProtKBPcellular response to heat
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 IDA:UniProtKBPfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0072163 IDA:UniProtKBPmesonephric epithelium development
GO:0007275 TAS:ProtIncPmulticellular organismal development
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0045766 IDA:UniProtKBPpositive regulation of angiogenesis
GO:0051781 IDA:UniProtKBPpositive regulation of cell division
GO:0030335 IDA:UniProtKBPpositive regulation of cell migration
GO:0008284 IGI:MGIPpositive regulation of cell proliferation
GO:0045542 IDA:BHF-UCLPpositive regulation of cholesterol biosynthetic process
GO:1902533 IDA:BHF-UCLPpositive regulation of intracellular signal transduction
GO:0045944 IDA:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0007165 NAS:ProtIncPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120863Activated point mutants of FGFR2
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_9400FGFR1b ligand binding and activation
REACT_9515FGFR1c ligand binding and activation
REACT_9483FGFR1 ligand binding and activation
REACT_9416FGFR2b ligand binding and activation
REACT_9413FGFR2c ligand binding and activation
REACT_9390FGFR2 ligand binding and activation
REACT_9508FGFR3b ligand binding and activation
REACT_9510FGFR3c ligand binding and activation
REACT_9439FGFR3 ligand binding and activation
REACT_9452FGFR4 ligand binding and activation
REACT_9396FGFR ligand binding and activation
REACT_21247FRS2-mediated cascade
REACT_12578GAB1 signalosome
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111184Negative regulation of FGFR signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21310Phospholipase C-mediated cascade
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_21374SHC-mediated cascade
REACT_121153Signaling by activated point mutants of FGFR1
REACT_121337Signaling by activated point mutants of FGFR3
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120999Signaling by FGFR1 mutants
REACT_121155Signaling by FGFR2 mutants
REACT_121249Signaling by FGFR3 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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