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MGP001065

UniProt Annotations

Entry Information
Gene Namefibroblast growth factor 1 (acidic)
Protein EntryFGF1_HUMAN
UniProt IDP05230
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P05230-1; Sequence=Displayed; Name=2; IsoId=P05230-2; Sequence=VSP_036536, VSP_036537;
FunctionPlays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:8663044}.
InteractionP11362:FGFR1; NbExp=3; IntAct=EBI-698068, EBI-1028277; P21802:FGFR2; NbExp=3; IntAct=EBI-698068, EBI-1028658; P22607:FGFR3; NbExp=3; IntAct=EBI-698068, EBI-348399;
PtmIn the nucleus, phosphorylated by PKC/PRKCD. {ECO:0000269|PubMed:22321063}.
SimilarityBelongs to the heparin-binding growth factors family. {ECO:0000305}.
Subcellular LocationSecreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. {ECO:0000250}.
SubunitMonomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1 (By similarity). Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. {ECO:0000250, ECO:0000269|PubMed:10618369, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11069186, ECO:0000269|PubMed:11432880, ECO:0000269|PubMed:11964394, ECO:0000269|PubMed:14732692, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:7521397, ECO:0000269|PubMed:8663044, ECO:0000269|PubMed:9655399}.
Tissue SpecificityPredominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. {ECO:0000269|PubMed:11964394, ECO:0000269|PubMed:7504343}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/fgf1/";
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