MGP Database

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MGP001363

UniProt Annotations

Entry Information
Gene Namegeneral transcription factor IIA, 2, 12kDa
Protein EntryT2AG_HUMAN
UniProt IDP52657
SpeciesHuman
Comments
Comment typeDescription
FunctionTFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333}.
InteractionP20226:TBP; NbExp=2; IntAct=EBI-1045262, EBI-355371;
SimilarityBelongs to the TFIIA subunit 2 family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitTFIIA is a heterodimer of the large unprocessed subunit 1 and a small subunit gamma. It was originally believed to be a heterotrimer of an alpha (p35), a beta (p19) and a gamma subunit (p12). Interacts with NCOA6 general coactivator (By similarity). TFIIA forms a complex with TBP. Interacts with SV40 Large T antigen. {ECO:0000250, ECO:0000269|PubMed:10567404, ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:9632777}.
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