MGP Database

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MGP001463

Ontology/Pathway Information

Entrez Gene ID3146
Gene Namehigh mobility group box 1
Gene Symbol HMGB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:UniProtKBCcell surface
GO:0000793 IDA:UniProtKBCcondensed chromosome
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0042056 ISS:UniProtKBFchemoattractant activity
GO:0003682 IBA:GO_CentralFchromatin binding
GO:0005125 ISS:UniProtKBFcytokine activity
GO:0003684 ISS:UniProtKBFdamaged DNA binding
GO:0008301 IMP:UniProtKBFDNA binding, bending
GO:0003690 ISS:UniProtKBFdouble-stranded DNA binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0050786 ISS:UniProtKBFRAGE receptor binding
GO:0070491 IPI:UniProtKBFrepressing transcription factor binding
GO:0003700 IDA:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0003697 ISS:UniProtKBFsingle-stranded DNA binding
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0006309 TAS:ReactomePapoptotic DNA fragmentation
GO:0006915 TAS:ReactomePapoptotic process
GO:0006288 IDA:UniProtKBPbase-excision repair, DNA ligation
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0006338 IBA:GO_CentralPchromatin remodeling
GO:0002407 ISS:UniProtKBPdendritic cell chemotaxis
GO:0051103 ISS:UniProtKBPDNA ligation involved in DNA repair
GO:0006310 ISS:UniProtKBPDNA recombination
GO:0006265 ISS:UniProtKBPDNA topological change
GO:0002437 IEP:UniProtKBPinflammatory response to antigenic stimulus
GO:0045087 TAS:ReactomePinnate immune response
GO:0001773 ISS:UniProtKBPmyeloid dendritic cell activation
GO:2000426 IEA:EnsemblPnegative regulation of apoptotic cell clearance
GO:0017055 IDA:UniProtKBPnegative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0000122 IMP:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0031175 ISS:UniProtKBPneuron projection development
GO:0050918 ISS:GOCPpositive chemotaxis
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0043280 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 IDA:UniProtKBPpositive regulation of DNA binding
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0006357 IDA:UniProtKBPregulation of transcription from RNA polymerase II promoter
GO:0033151 IDA:UniProtKBPV(D)J recombination
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_13462Activation of DNA fragmentation factor
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_578Apoptosis
REACT_1213Apoptosis induced DNA fragmentation
REACT_995Apoptotic execution phase
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_268456Programmed Cell Death
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_24969TRAF6 mediated NF-kB activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
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