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MGP001463

UniProt Annotations

Entry Information
Gene Namehigh mobility group box 1
Protein EntryHMGB1_HUMAN
UniProt IDP09429
SpeciesHuman
Comments
Comment typeDescription
FunctionDNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity). {ECO:0000250}.
SimilarityBelongs to the HMGB family. {ECO:0000305}.
SimilarityContains 2 HMG box DNA-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00267}.
Subcellular LocationNucleus. Chromosome.
SubunitComponent of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. {ECO:0000250}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/hmgb1/";
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