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MGP001535

UniProt Annotations

Entry Information
Gene Name5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
Protein Entry5HT4R_HUMAN
UniProt IDQ13639
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist.; Name=5-HT4(B); IsoId=Q13639-1; Sequence=Displayed; Name=5-HT4(A); Synonyms=5-HT4S; IsoId=Q13639-2; Sequence=VSP_001849; Name=5-HT4(C); IsoId=Q13639-3; Sequence=VSP_001848; Name=5-HT4(D); IsoId=Q13639-4; Sequence=VSP_001847; Name=5-HT4(E); Synonyms=H5-HT4(g); IsoId=Q13639-5; Sequence=VSP_001846; Note=Mainly expressed in atria and cardiac ventricle.; Name=5-HT4(F); IsoId=Q13639-6; Sequence=VSP_001845; Name=5-HT4(G); IsoId=Q13639-7; Sequence=VSP_001850; Name=5-HT4(I); IsoId=Q13639-8; Sequence=VSP_043316; Note=Expressed in all cardiovascular tissues analyzed.; Name=5-HT4c1; IsoId=Q13639-9; Sequence=VSP_047862;
FunctionThis is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.
SubunitIsoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330- 346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin). {ECO:0000250, ECO:0000269|PubMed:19661922}.
Tissue SpecificityIsoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. {ECO:0000269|PubMed:15118808}.
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