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MGP001539

Record overview

MGPD IDMGP001539
Gene ID3364
SpeciesHomo sapiens (Human)
Gene NameHUS1 checkpoint homolog (S. pombe)
Gene Symbol HUS1
SynonymshHUS1;
Alternate namescheckpoint protein HUS1; hus1+-like protein;
Chromosome7
Map Location7p13-p12
SummaryThe protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
OrthologsView orthologs and multiple alignments for HUS1

Proteins

checkpoint protein HUS1
Refseq ID:NP_004498
Protein GI:4758576
UniProt ID:O60921
mRNA ID:NM_004507
Length:280
RefSeq Status:
MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARA
LKIKLTNKHFPCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHLVIEANLDGELNLKIETELVC
VTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
 
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