MGP Database

MGP001660

Ontology/Pathway Information

Entrez Gene ID	3673
Gene Name	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Gene Symbol	ITGA2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0043679	IEA:Ensembl	C	axon terminus
GO:0045178	IEA:Ensembl	C	basal part of cell
GO:0009279	IEA:Ensembl	C	cell outer membrane
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005925	IDA:UniProtKB	C	focal adhesion
GO:0034666	IDA:UniProtKB	C	integrin alpha2-beta1 complex
GO:0008305	TAS:ProtInc	C	integrin complex
GO:0005634	IEA:Ensembl	C	nucleus
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005886	IDA:BHF-UCL	C	plasma membrane
GO:0005518	IMP:UniProtKB	F	collagen binding
GO:0098639	IMP:UniProtKB	F	collagen binding involved in cell-matrix adhesion
GO:0038064	IMP:UniProtKB	F	collagen receptor activity
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0001618	IEA:UniProtKB-KW	F	virus receptor activity
GO:0007411	TAS:Reactome	P	axon guidance
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0007155	TAS:ProtInc	P	cell adhesion
GO:0033627	IMP:UniProtKB	P	cell adhesion mediated by integrin
GO:0007160	IMP:UniProtKB	P	cell-matrix adhesion
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0031589	IMP:UniProtKB	P	cell-substrate adhesion
GO:0032870	IEA:Ensembl	P	cellular response to hormone stimulus
GO:0038065	IMP:UniProtKB	P	collagen-activated signaling pathway
GO:0050966	IEA:Ensembl	P	detection of mechanical stimulus involved in sensory perception of pain
GO:0045184	IEA:Ensembl	P	establishment of protein localization
GO:0030198	TAS:Reactome	P	extracellular matrix organization
GO:0070365	IEA:Ensembl	P	hepatocyte differentiation
GO:0006971	IEA:Ensembl	P	hypotonic response
GO:0007229	IMP:UniProtKB	P	integrin-mediated signaling pathway
GO:0030879	IEA:Ensembl	P	mammary gland development
GO:0048333	IEP:UniProtKB	P	mesodermal cell differentiation
GO:0009887	TAS:ProtInc	P	organ morphogenesis
GO:0010694	IEA:Ensembl	P	positive regulation of alkaline phosphatase activity
GO:0045785	IEA:Ensembl	P	positive regulation of cell adhesion
GO:0031346	IEA:Ensembl	P	positive regulation of cell projection organization
GO:0033343	IEA:Ensembl	P	positive regulation of collagen binding
GO:0032967	IEA:Ensembl	P	positive regulation of collagen biosynthetic process
GO:0043388	IEA:Ensembl	P	positive regulation of DNA binding
GO:0010634	IEA:Ensembl	P	positive regulation of epithelial cell migration
GO:0050729	IEA:Ensembl	P	positive regulation of inflammatory response
GO:0002687	IEA:Ensembl	P	positive regulation of leukocyte migration
GO:0060100	IEA:Ensembl	P	positive regulation of phagocytosis, engulfment
GO:0050927	IEA:Ensembl	P	positive regulation of positive chemotaxis
GO:0014911	IEA:Ensembl	P	positive regulation of smooth muscle cell migration
GO:0048661	IEA:Ensembl	P	positive regulation of smooth muscle cell proliferation
GO:0045987	IEA:Ensembl	P	positive regulation of smooth muscle contraction
GO:0045727	IEA:Ensembl	P	positive regulation of translation
GO:0051971	IEA:Ensembl	P	positive regulation of transmission of nerve impulse
GO:0014075	IEA:Ensembl	P	response to amine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0033591	IEA:Ensembl	P	response to L-ascorbic acid
GO:0014850	IEA:Ensembl	P	response to muscle activity
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0043589	IEA:Ensembl	P	skin morphogenesis
GO:0006929	IMP:UniProtKB	P	substrate-dependent cell migration
GO:0016032	IEA:UniProtKB-KW	P	viral process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_18266	Axon guidance
REACT_22292	CHL1 interactions
REACT_111045	Developmental Biology
REACT_163906	ECM proteoglycans
REACT_118779	Extracellular matrix organization
REACT_604	Hemostasis
REACT_13552	Integrin cell surface interactions
REACT_22205	L1CAM interactions
REACT_169262	Laminin interactions
REACT_163874	Non-integrin membrane-ECM interactions
REACT_1230	Platelet Adhesion to exposed collagen
REACT_163942	Syndecan interactions