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MGP001660

UniProt Annotations

Entry Information
Gene Nameintegrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Protein EntryITA2_HUMAN
UniProt IDP17301
SpeciesHuman
Comments
Comment typeDescription
DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
FunctionIntegrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
InteractionP05556:ITGB1; NbExp=3; IntAct=EBI-702960, EBI-703066; P35968:KDR; NbExp=2; IntAct=EBI-702960, EBI-1005487; P35282:Rab21 (xeno); NbExp=7; IntAct=EBI-702960, EBI-1993555; Q9H0F6:SHARPIN; NbExp=5; IntAct=EBI-702960, EBI-3942966;
PolymorphismPosition 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).
SimilarityBelongs to the integrin alpha chain family. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 FG-GAP repeats. {ECO:0000305}.
Subcellular LocationMembrane; Single-pass type I membrane protein.
SubunitHeterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor. {ECO:0000269|PubMed:12941907, ECO:0000269|PubMed:16754960, ECO:0000269|PubMed:8411387}.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/itga2/";
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