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MGP001789

Record overview

MGPD IDMGP001789
Gene ID3906
SpeciesHomo sapiens (Human)
Gene Namelactalbumin, alpha-
Gene Symbol LALBA
Alternate namesalpha-lactalbumin; lactose synthase B protein; lysozyme-like protein 7;
Chromosome12
Map Location12q13
SummaryThis gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LALBA

Proteins

alpha-lactalbumin precursor
Refseq ID:NP_002280
Protein GI:4504947
UniProt ID:P00709
mRNA ID:NM_002289
Length:142
RefSeq Status:
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFL
DDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWLCEKL
 
sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2165
peptide sequence: 
MRFFVPLFLVGILFPAILA

mat_peptide: 20..142
product: alpha-lactalbumin
calculated_mol_wt: 14078
peptide sequence: 
KQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKG
IDYWLAHKALCTEKLEQWLCEKL
 
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