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MGP002388

Record overview

MGPD IDMGP002388
Gene ID5499
SpeciesHomo sapiens (Human)
Gene Nameprotein phosphatase 1, catalytic subunit, alpha isozyme
Gene Symbol PPP1CA
SynonymsPP1A; PP-1A; PPP1A; PP1alpha;
Alternate namesserine/threonine-protein phosphatase PP1-alpha catalytic subunit; protein phosphatase 1, catalytic subunit, alpha isoform; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit;
Chromosome11
Map Location11q13
EC Number3.1.3.16;
SummaryThe protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PPP1CA

Proteins

serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 1
Refseq ID:NP_002699
Protein GI:4506003
UniProt ID:P62136
mRNA ID:NM_002708
Length:330
RefSeq Status:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQS
LETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGL
LCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
 
serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 2
Refseq ID:NP_996756
Protein GI:45827798
UniProt ID:P62136
mRNA ID:NM_206873
Length:286
RefSeq Status:
MSDSEKLNLDSIIGRLLEGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY
NIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLI
CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
 
serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3
Refseq ID:NP_001008709
Protein GI:56790945
UniProt ID:P62136
mRNA ID:NM_001008709
Length:341
RefSeq Status:
MSDSEKLNLDSIIGRLLEGSRVLTPHCAPVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLF
LGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRI
MRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETL
MCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
 
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