MGP Database

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MGP002388

Ontology/Pathway Information

Entrez Gene ID5499
Gene Nameprotein phosphatase 1, catalytic subunit, alpha isozyme
Gene Symbol PPP1CA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0043197 IEA:EnsemblCdendritic spine
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0042587 IEA:EnsemblCglycogen granule
GO:0070688 IDA:UniProtKBCMLL5-L complex
GO:0005730 IEA:UniProtKB-SubCellCnucleolus
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0043204 IEA:EnsemblCperikaryon
GO:0005886 IDA:HPACplasma membrane
GO:0000164 IEA:EnsemblCprotein phosphatase type 1 complex
GO:0072357 IDA:UniProtKBCPTW/PP1 phosphatase complex
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0016791 ISS:UniProtKBFphosphatase activity
GO:0004722 TAS:ProtIncFprotein serine/threonine phosphatase activity
GO:0043021 IEA:EnsemblFribonucleoprotein complex binding
GO:0048754 IEA:EnsemblPbranching morphogenesis of an epithelial tube
GO:0007049 IEA:UniProtKB-KWPcell cycle
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0043153 ISS:UniProtKBPentrainment of circadian clock by photoperiod
GO:0005977 IEA:UniProtKB-KWPglycogen metabolic process
GO:0030324 IEA:EnsemblPlung development
GO:0030512 TAS:ReactomePnegative regulation of transforming growth factor beta receptor signaling pathway
GO:2001241 IEA:EnsemblPpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0006470 ISS:UniProtKBPprotein dephosphorylation
GO:0042752 IMP:UniProtKBPregulation of circadian rhythm
GO:0005979 IEA:EnsemblPregulation of glycogen biosynthetic process
GO:0005981 IEA:EnsemblPregulation of glycogen catabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
GO:0019433 TAS:ReactomePtriglyceride catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_15334DARPP-32 events
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_494Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_602Lipid digestion, mobilization, and transport
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_15295Opioid Signalling
REACT_14797Signaling by GPCR
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
SMP Pathway Links
SMP IDDescription
SMP00309Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
SMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
SMP00311Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
SMP00333Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
SMP00335Intracellular Signalling Through Histamine H2 Receptor and Histamine
SMP00338Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
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