MGP Database

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MGP002392

Ontology/Pathway Information

Entrez Gene ID5515
Gene Nameprotein phosphatase 2, catalytic subunit, alpha isozyme
Gene Symbol PPP2CA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000775 IEA:UniProtKB-SubCellCchromosome, centromeric region
GO:0005829 TAS:UniProtKBCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 NAS:UniProtKBCmembrane
GO:0015630 NAS:UniProtKBCmicrotubule cytoskeleton
GO:0005739 NAS:UniProtKBCmitochondrion
GO:0005634 NAS:UniProtKBCnucleus
GO:0005886 IEA:EnsemblCplasma membrane
GO:0000159 IDA:UniProtKBCprotein phosphatase type 2A complex
GO:0000922 IEA:UniProtKB-SubCellCspindle pole
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0004722 IEA:EnsemblFprotein serine/threonine phosphatase activity
GO:0006915 TAS:UniProtKBPapoptotic process
GO:0006672 NAS:UniProtKBPceramide metabolic process
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0010467 TAS:ReactomePgene expression
GO:0000188 NAS:UniProtKBPinactivation of MAPK activity
GO:0051321 IEA:UniProtKB-KWPmeiotic cell cycle
GO:0007498 IEA:EnsemblPmesoderm development
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0007084 TAS:ReactomePmitotic nuclear envelope reassembly
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0030308 NAS:UniProtKBPnegative regulation of cell growth
GO:0010719 IMP:BHF-UCLPnegative regulation of epithelial to mesenchymal transition
GO:0042518 NAS:UniProtKBPnegative regulation of tyrosine phosphorylation of Stat3 protein
GO:0000184 TAS:ReactomePnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0071902 IMP:BHF-UCLPpositive regulation of protein serine/threonine kinase activity
GO:0006470 TAS:UniProtKBPprotein dephosphorylation
GO:0070208 IEA:EnsemblPprotein heterotrimerization
GO:0030155 NAS:UniProtKBPregulation of cell adhesion
GO:0045595 NAS:UniProtKBPregulation of cell differentiation
GO:0006275 NAS:UniProtKBPregulation of DNA replication
GO:0040008 NAS:UniProtKBPregulation of growth
GO:0031952 IEA:EnsemblPregulation of protein autophosphorylation
GO:0042176 IEA:EnsemblPregulation of protein catabolic process
GO:0010469 IEA:EnsemblPregulation of receptor activity
GO:0006355 NAS:UniProtKBPregulation of transcription, DNA-templated
GO:0030111 NAS:UniProtKBPregulation of Wnt signaling pathway
GO:0010033 NAS:UniProtKBPresponse to organic substance
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0008380 NAS:UniProtKBPRNA splicing
GO:0019932 NAS:UniProtKBPsecond-messenger-mediated signaling
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_75774Adaptive Immune System
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_11065Beta-catenin phosphorylation cascade
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_821Cyclin D associated events in G1
REACT_15334DARPP-32 events
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_264034disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125Disease
REACT_471E2F mediated regulation of DNA replication
REACT_12599ERK/MAPK targets
REACT_12436ERKs are inactivated
REACT_1590G1 Phase
REACT_1783G1/S Transition
REACT_2203G2/M Transition
REACT_71Gene Expression
REACT_723Glucose metabolism
REACT_264090Glycogen storage diseases
REACT_1383Glycolysis
REACT_604Hemostasis
REACT_6900Immune System
REACT_329Inhibition of replication initiation of damaged DNA by RB1/E2F1
REACT_160242Initiation of Nuclear Envelope Reformation
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_150182MASTL Facilitates Mitotic Progression
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_1275Mitotic Anaphase
REACT_21267Mitotic G1-G1/S phases
REACT_21391Mitotic G2-G2/M phases
REACT_150314Mitotic Metaphase and Anaphase
REACT_682Mitotic Prometaphase
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_264430Myoclonic epilepsy of Lafora
REACT_111184Negative regulation of FGFR signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_75886Nonsense-Mediated Decay (NMD)
REACT_75822Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
REACT_160113Nuclear Envelope Reassembly
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_15295Opioid Signalling
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_23876Platelet homeostasis
REACT_23879Platelet sensitization by LDL
REACT_705PP2A-mediated dephosphorylation of key metabolic factors
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_150471Separation of Sister Chromatids
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_111080Spry regulation of FGF signaling
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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