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MGP002477

Record overview

MGPD IDMGP002477
Gene ID5690
SpeciesHomo sapiens (Human)
Gene Nameproteasome (prosome, macropain) subunit, beta type, 2
Gene Symbol PSMB2
SynonymsHC7-I;
Alternate namesproteasome subunit beta type-2; macropain subunit C7-I; multicatalytic endopeptidase complex subunit C7-1; multicatalytic endopeptidase complex subunit C7-I; proteasome beta 2 subunit; proteasome component C7-I; proteasome subunit, beta type, 2;
Chromosome1
Map Location1p34.2
EC Number3.4.25.1
SummaryThe proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
OrthologsView orthologs and multiple alignments for PSMB2

Proteins

proteasome subunit beta type-2 isoform 1
Refseq ID:NP_002785
Protein GI:4506195
UniProt ID:P49721
mRNA ID:NM_002794
Length:201
RefSeq Status:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHV
NLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQG
S
 
proteasome subunit beta type-2 isoform 2
Refseq ID:NP_001186708
Protein GI:315139006
UniProt ID:B7Z478
mRNA ID:NM_001199779
Length:176
RefSeq Status:
MEYLIDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALA
KAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
 
proteasome subunit beta type-2 isoform 3
Refseq ID:NP_001186709
Protein GI:315139004
UniProt ID:
mRNA ID:NM_001199780
Length:84
RefSeq Status:
MDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
 
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