MGP Database

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MGP002477

UniProt Annotations

Entry Information
Gene Nameproteasome (prosome, macropain) subunit, beta type, 2
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCleavage of peptide bonds with very broad specificity.
FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit has a trypsin-like activity.
InductionUp-regulated in ovarian cancer cell lines. {ECO:0000269|PubMed:19787249}.
InteractionP49720:PSMB3; NbExp=4; IntAct=EBI-359335, EBI-603340;
SimilarityBelongs to the peptidase T1B family. {ECO:0000255|PROSITE-ProRule:PRU00809}.
Subcellular LocationCytoplasm. Nucleus.
SubunitThe 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with HIV-1 TAT protein. {ECO:0000269|PubMed:14550573}.
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