MGP Database

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MGP002564

Record overview

MGPD IDMGP002564
Gene ID5885
SpeciesHomo sapiens (Human)
Gene NameRAD21 homolog (S. pombe)
Gene Symbol RAD21
SynonymsHR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21;
Alternate namesdouble-strand-break repair protein rad21 homolog; NXP-1; SCC1 homolog; nuclear matrix protein 1; protein involved in DNA double-strand break repair; sister chromatid cohesion 1;
Chromosome8
Map Location8q24
SummaryThe protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RAD21

Proteins

double-strand-break repair protein rad21 homolog
Refseq ID:NP_006256
Protein GI:5453994
UniProt ID:O60216
mRNA ID:NM_006265
Length:631
RefSeq Status:
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEEN
REAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLESEQSTS
NLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNE
EEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPED
LRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIP
PVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSF
LVLKKQQAIELTQEEPYSDIIATPGPRFHII
 
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