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MGP002615

Record overview

MGPD IDMGP002615
Gene ID5984
SpeciesHomo sapiens (Human)
Gene Namereplication factor C (activator 1) 4, 37kDa
Gene Symbol RFC4
SynonymsA1; RFC37;
Alternate namesreplication factor C subunit 4; A1 37 kDa subunit; RF-C 37 kDa subunit; RFC 37 kDa subunit; activator 1 37 kDa subunit; activator 1 subunit 4; replication factor C 37 kDa subunit;
Chromosome3
Map Location3q27
SummaryThe elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RFC4

Proteins

replication factor C subunit 4
Refseq ID:NP_853551
Protein GI:31881687
UniProt ID:P35249
mRNA ID:NM_181573
Length:363
RefSeq Status:
MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPEL
FRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFK
PLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVITDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDLIDEG
HAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVDKCLADGADEHLQLISLCATVMQQLSQNC
 
replication factor C subunit 4
Refseq ID:NP_002907
Protein GI:4506491
UniProt ID:P35249
mRNA ID:NM_002916
Length:363
RefSeq Status:
Protein sequence is identical to GI:31881687 (mRNA isoform)
 
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