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MGP002615

UniProt Annotations

Entry Information
Gene Namereplication factor C (activator 1) 4, 37kDa
Protein EntryRFC4_HUMAN
UniProt IDP35249
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35249-1; Sequence=Displayed; Name=2; IsoId=P35249-2; Sequence=VSP_055862, VSP_055863; Note=No experimental confirmation available.;
FunctionThe elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.
InteractionP35250:RFC2; NbExp=8; IntAct=EBI-476655, EBI-476409; P40938:RFC3; NbExp=5; IntAct=EBI-476655, EBI-1055010; P40937:RFC5; NbExp=6; IntAct=EBI-476655, EBI-712376;
MiscellaneousDespite of the presence of a putative ATP-binding motif, this protein does not bind ATP.
SimilarityBelongs to the activator 1 small subunits family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitHeterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. {ECO:0000269|PubMed:11572977}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rfc4/";
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