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MGP002636

Record overview

MGPD IDMGP002636
Gene ID6049
SpeciesHomo sapiens (Human)
Gene Namering finger protein (C3H2C3 type) 6
Gene Symbol RNF6
Alternate namesE3 ubiquitin-protein ligase RNF6; RING-H2 protein RNF-6;
Chromosome13
Map Location13q12.2
EC Number6.3.2.-;
SummaryThe protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for RNF6

Proteins

E3 ubiquitin-protein ligase RNF6
Refseq ID:NP_898864
Protein GI:34305293
UniProt ID:Q9Y252
mRNA ID:NM_183043
Length:685
RefSeq Status:
MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNLLGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEV
PRESSHEDSLLEWLNTFRRTGNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRDHTANRQQRSTSPVARRTRSQ
TSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEP
IRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVFLEQDRERERRGTAYTPFSNSRLVSRITVEEGEESSRSSTAVRRHPTITLD
LQVRRIRPGENRDRDSIANRTRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSSVALRSILRQIMTGFGELSSLMEA
DSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDRQAQGDSTEMHGENETTQPHTRNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDD
DRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGSNIANNG
 
E3 ubiquitin-protein ligase RNF6
Refseq ID:NP_898865
Protein GI:34305295
UniProt ID:Q9Y252
mRNA ID:NM_183044
Length:685
RefSeq Status:
Protein sequence is identical to GI:34305293 (mRNA isoform)
 
E3 ubiquitin-protein ligase RNF6
Refseq ID:NP_005968
Protein GI:5174653
UniProt ID:Q9Y252
mRNA ID:NM_005977
Length:685
RefSeq Status:
Protein sequence is identical to GI:34305293 (mRNA isoform)
 
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