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MGP002636

UniProt Annotations

Entry Information
Gene Namering finger protein (C3H2C3 type) 6
Protein EntryRNF6_HUMAN
UniProt IDQ9Y252
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y252-1; Sequence=Displayed; Name=2; IsoId=Q9Y252-2; Sequence=VSP_055424, VSP_055425; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y252-3; Sequence=VSP_055426, VSP_055427;
Developmental StageExpressed in embryo and adult testis. {ECO:0000269|PubMed:18368307}.
DiseaseEsophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269|PubMed:12154016}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
FunctionE3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:19345326}.
InteractionP10275:AR; NbExp=10; IntAct=EBI-2341483, EBI-608057;
MiscellaneousRequired for prostate tumor cell growth.
PathwayProtein modification; protein ubiquitination.
SimilarityBelongs to the RNF12 family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
Subcellular LocationNucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}.
SubunitInteracts with LIMK1 (By similarity). Interacts with AR. {ECO:0000250, ECO:0000269|PubMed:19345326}.
Tissue SpecificityWeakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. {ECO:0000269|PubMed:18368307, ECO:0000269|PubMed:19345326}.
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