MGP Database

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MGP002699

UniProt Annotations

Entry Information
Gene Nameribosomal protein S6
Protein EntryRS6_HUMAN
UniProt IDP62753
SpeciesHuman
Comments
Comment typeDescription
FunctionMay play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
InteractionQ09161:NCBP1; NbExp=3; IntAct=EBI-356625, EBI-464743; Q96RG2:PASK; NbExp=3; IntAct=EBI-356625, EBI-1042651;
PtmRibosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex. {ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18974095, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:21418524}.
SimilarityBelongs to the ribosomal protein S6e family. {ECO:0000305}.
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