MGP Database

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MGP003143

Ontology/Pathway Information

Entrez Gene ID7089
Gene Nametransducin-like enhancer of split 2
Gene Symbol TLE2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005615 IDA:UniProtKBCextracellular space
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 TAS:ProtIncCnucleus
GO:0003714 IDA:UniProtKBFtranscription corepressor activity
GO:0090090 IDA:UniProtKBPnegative regulation of canonical Wnt signaling pathway
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0009887 TAS:ProtIncPorgan morphogenesis
GO:0007165 TAS:ProtIncPsignal transduction
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_264178deactivation of the beta-catenin transactivating complex
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_264242formation of the beta-catenin:TCF transactivating complex
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_264567repression of WNT target genes
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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