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MGP003143

UniProt Annotations

Entry Information
Gene Nametransducin-like enhancer of split 2
Protein EntryTLE2_HUMAN
UniProt IDQ04725
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q04725-1; Sequence=Displayed; Name=2; IsoId=Q04725-2; Sequence=VSP_045693, VSP_045694; Note=No experimental confirmation available.; Name=3; IsoId=Q04725-3; Sequence=VSP_046162, VSP_046163, VSP_046164; Note=No experimental confirmation available.;
FunctionTranscriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
InteractionQ16531:DDB1; NbExp=2; IntAct=EBI-1176061, EBI-350322;
PtmUbiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
Sequence CautionSequence=AK308137; Type=Frameshift; Positions=537; Evidence={ECO:0000305};
SimilarityBelongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
SimilarityContains 6 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationNucleus.
SubunitHomooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.
Tissue SpecificityIn all tissues examined, mostly in heart, brain, and muscle.
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