MGP Database

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MGP003251

Ontology/Pathway Information

Entrez Gene ID7334
Gene Nameubiquitin-conjugating enzyme E2N
Gene Symbol UBE2N
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005634 IDA:UniProtKBCnucleus
GO:0043234 IDA:MGICprotein complex
GO:0031372 IDA:HGNCCUBC13-MMS2 complex
GO:0035370 IDA:UniProtKBCUBC13-UEV1A complex
GO:0000151 IDA:UniProtKBCubiquitin ligase complex
GO:0016881 IEA:InterProFacid-amino acid ligase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0019787 IBA:GO_CentralFsmall conjugating protein transferase activity
GO:0043130 IDA:HGNCFubiquitin binding
GO:0061630 IBA:GO_CentralFubiquitin protein ligase activity
GO:0031625 IBA:GO_CentralFubiquitin protein ligase binding
GO:0004842 IDA:UniProtKBFubiquitin-protein transferase activity
GO:0006464 TAS:ProtIncPcellular protein modification process
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0000729 IMP:HGNCPDNA double-strand break processing
GO:0000724 IMP:HGNCPdouble-strand break repair via homologous recombination
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0016574 IMP:HGNCPhistone ubiquitination
GO:0045087 TAS:ReactomePinnate immune response
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0070423 TAS:ReactomePnucleotide-binding oligomerization domain containing signaling pathway
GO:0045739 IMP:HGNCPpositive regulation of DNA repair
GO:0031058 IMP:HGNCPpositive regulation of histone modification
GO:0043123 IMP:HGNCPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092 IMP:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0051443 IMP:HGNCPpositive regulation of ubiquitin-protein transferase activity
GO:0006301 IMP:HGNCPpostreplication repair
GO:0070534 IDA:UniProtKBPprotein K63-linked ubiquitination
GO:0016567 IMP:HGNCPprotein ubiquitination
GO:0006508 TAS:ProtIncPproteolysis
GO:0006282 TAS:ProtIncPregulation of DNA repair
GO:0033182 IMP:HGNCPregulation of histone ubiquitination
GO:0050852 IMP:UniProtKBPT cell receptor signaling pathway
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0006511 IEA:EnsemblPubiquitin-dependent protein catabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_75774Adaptive Immune System
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_75790Cytokine Signaling in Immune system
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_25374IKK complex recruitment mediated by RIP1
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_25229Interferon Signaling
REACT_22442Interleukin-1 signaling
REACT_24918IRAK1 recruits IKK complex
REACT_25354IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
REACT_115831ISG15 antiviral mechanism
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_22232Signaling by Interleukins
REACT_12526TCR signaling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25120TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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