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MGP003295

Record overview

MGPD IDMGP003295
Gene ID7424
SpeciesHomo sapiens (Human)
Gene Namevascular endothelial growth factor C
Gene Symbol VEGFC
SynonymsVRP; Flt4-L; LMPH1D;
Alternate namesvascular endothelial growth factor C; FLT4 ligand DHM; vascular endothelial growth factor-related protein;
Chromosome4
Map Location4q34.3
SummaryThe protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for VEGFC

Proteins

vascular endothelial growth factor C preproprotein
Refseq ID:NP_005420
Protein GI:4885653
UniProt ID:P49767
mRNA ID:NM_005429
Length:419
RefSeq Status:
MHLLGFFSVACSLLAAALLPGPREAPAAAAAFESGLDLSDAEPDAGEATAYASKDLEEQLRSVSSVDELMTVLYPEYWKMYKCQLRKGGWQHNREQANLN
SRTEETIKFAAAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVT
ISFANHTSCRCMSKLDVYRQVHSIIRRSLPATLPQCQAANKTCPTNYMWNNHICRCLAQEDFMFSSDAGDDSTDGFHDICGPNKELDEETCQCVCRAGLR
PASCGPHKELDRNSCQCVCKNKLFPSQCGANREFDENTCQCVCKRTCPRNQPLNPGKCACECTESPQKCLLKGKKFHHQTCSCYRRPCTNRQKACEPGFS
YSEEVCRCVPSYWKRPQMS
 
sig_peptide: 1..31
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49767.1)
calculated_mol_wt: 3038
peptide sequence: 
MHLLGFFSVACSLLAAALLPGPREAPAAAAA

mat_peptide: 112..227
product: Vascular endothelial growth factor C
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P49767.1)
calculated_mol_wt: 13104
peptide sequence: 
AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRC
MSKLDVYRQVHSIIRR
 
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