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MGP004028

UniProt Annotations

Entry Information

Gene Name	GRB2-associated binding protein 2
Protein Entry	GAB2_HUMAN
UniProt ID	Q9UQC2
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UQC2-1; Sequence=Displayed; Name=2; IsoId=Q9UQC2-2; Sequence=VSP_038520;
Domain	The PH domain mediates phosphatidylinositol 3,4,5- trisphosphate and phosphatidylinositol 3,4-bisphosphate binding. {ECO:0000250}.
Domain	The SH3-binding motifs mediate interaction with SHC1 and GRB2. {ECO:0000250}.
Function	Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269\|PubMed:15750601, ECO:0000269\|PubMed:19172738}.
Interaction	P62993:GRB2; NbExp=14; IntAct=EBI-975200, EBI-401755; Q06124:PTPN11; NbExp=4; IntAct=EBI-975200, EBI-297779; P31946:YWHAB; NbExp=4; IntAct=EBI-975200, EBI-359815;
Ptm	Dephosphorylated by PTPN11.
Ptm	Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. {ECO:0000250, ECO:0000269\|PubMed:15010462, ECO:0000269\|PubMed:18669648, ECO:0000269\|PubMed:19172738}.
Sequence Caution	Sequence=BAA25497.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Belongs to the GAB family. {ECO:0000305}.
Similarity	Contains 1 PH domain. {ECO:0000255\|PROSITE- ProRule:PRU00145}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:19172738}. Cell membrane {ECO:0000269\|PubMed:19172738}.
Subunit	Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK. {ECO:0000250, ECO:0000269\|PubMed:10068651, ECO:0000269\|PubMed:15010462, ECO:0000269\|PubMed:15750601, ECO:0000269\|PubMed:19172738, ECO:0000269\|PubMed:19523899}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/GAB2ID40664ch11q14.html";