MGP Database

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MGP004304

Ontology/Pathway Information

Entrez Gene ID10606
Gene Namephosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Symbol PAICS
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0004638 TAS:ReactomeFphosphoribosylaminoimidazole carboxylase activity
GO:0004639 TAS:ReactomeFphosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0006189 IEA:UniProtKB-UniPathwayP'de novo' IMP biosynthetic process
GO:0055086 TAS:ReactomePnucleobase-containing small molecule metabolic process
GO:0009113 TAS:ProtIncPpurine nucleobase biosynthetic process
GO:0006144 TAS:ReactomePpurine nucleobase metabolic process
GO:0009168 TAS:ReactomePpurine ribonucleoside monophosphate biosynthetic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_1698Metabolism of nucleotides
REACT_522Purine metabolism
REACT_1776Purine ribonucleoside monophosphate biosynthesis
SMP Pathway Links
SMP IDDescription
SMP00535Adenine phosphoribosyltransferase deficiency (APRT)
SMP00144Adenosine Deaminase Deficiency
SMP00167Adenylosuccinate Lyase Deficiency
SMP00168AICA-Ribosiduria
SMP00427Azathioprine Action Pathway
SMP00365Gout or Kelley-Seegmiller Syndrome
SMP00364Lesch-Nyhan Syndrome (LNS)
SMP00428Mercaptopurine Action Pathway
SMP00536Mitochondrial DNA depletion syndrome
SMP00203Molybdenum Cofactor Deficiency
SMP00537Myoadenylate deaminase deficiency
SMP00050Purine Metabolism
SMP00210Purine Nucleoside Phosphorylase Deficiency
SMP00430Thioguanine Action Pathway
SMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
SMP00512Xanthinuria type I
SMP00513Xanthinuria type II
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