MGP Database

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MGP004304

UniProt Annotations

Entry Information
Gene Namephosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
Protein EntryPUR6_HUMAN
UniProt IDP22234
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22234-1; Sequence=Displayed; Name=2; IsoId=P22234-2; Sequence=VSP_041265;
Catalytic Activity5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
Catalytic ActivityATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate.
InteractionSelf; NbExp=3; IntAct=EBI-712261, EBI-712261; P51116:FXR2; NbExp=3; IntAct=EBI-712261, EBI-740459; Q6ZVK8:NUDT18; NbExp=3; IntAct=EBI-712261, EBI-740486;
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5- amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
SimilarityIn the C-terminal section; belongs to the AIR carboxylase family. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the SAICAR synthetase family. {ECO:0000305}.
SubunitHomooctamer. {ECO:0000269|PubMed:17224163}.
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