MGP Database

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MGP004372

Ontology/Pathway Information

Entrez Gene ID10825
Gene Namesialidase 3 (membrane sialidase)
Gene Symbol NEU3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0005886 IDA:MGICplasma membrane
GO:0016997 IDA:MGIFalpha-sialidase activity
GO:0052794 ISS:UniProtKBFexo-alpha-(2->3)-sialidase activity
GO:0052795 IEA:UniProtKB-ECFexo-alpha-(2->6)-sialidase activity
GO:0052796 ISS:UniProtKBFexo-alpha-(2->8)-sialidase activity
GO:0004308 IDA:UniProtKBFexo-alpha-sialidase activity
GO:0005975 IDA:MGIPcarbohydrate metabolic process
GO:0006689 IDA:UniProtKBPganglioside catabolic process
GO:0006687 TAS:ReactomePglycosphingolipid metabolic process
GO:0009313 IDA:UniProtKBPoligosaccharide catabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006665 TAS:ReactomePsphingolipid metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22426Asparagine N-linked glycosylation
REACT_22433Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REACT_268132Defective ALG11 causes ALG11-CDG (CDG-1p)
REACT_267773Defective ALG12 causes ALG12-CDG (CDG-1g)
REACT_268645Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
REACT_268144Defective ALG1 causes ALG1-CDG (CDG-1k)
REACT_268833Defective ALG2 causes ALG2-CDG (CDG-1i)
REACT_268185Defective ALG3 causes ALG3-CDG (CDG-1d)
REACT_267765Defective ALG6 causes ALG6-CDG (CDG-1c)
REACT_268459Defective ALG8 causes ALG8-CDG (CDG-1h)
REACT_268015Defective ALG9 causes ALG9-CDG (CDG-1l)
REACT_268438Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268849Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
REACT_268813Defective MAN1B1 causes MRT15
REACT_268600Defective MGAT2 causes MGAT2-CDG (CDG-2a)
REACT_267905Defective MOGS causes MOGS-CDG (CDG-2b)
REACT_268619Defective MPDU1 causes MPDU1-CDG (CDG-1f)
REACT_268458Defective RFT1 causes RFT1-CDG (CDG-1n)
REACT_116125Disease
REACT_267875Diseases associated with N-glycosylation of proteins
REACT_268324Diseases of glycosylation
REACT_116105Glycosphingolipid metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_17015Metabolism of proteins
REACT_22161Post-translational protein modification
REACT_264366Sialic acid metabolism
REACT_19323Sphingolipid metabolism
REACT_22387Synthesis of substrates in N-glycan biosythesis
SMP Pathway Links
SMP IDDescription
SMP00525Fabry disease
SMP00349Gaucher Disease
SMP00348Globoid Cell Leukodystrophy
SMP00526Krabbe disease
SMP00347Metachromatic Leukodystrophy (MLD)
SMP00034Sphingolipid Metabolism
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